Long-acting amylin analog (obesity / diabetes)

Amylin is a pancreatic peptide hormone that plays an important role in decreasing food intake and in the regulation of postprandial plasma glucose levels. The compound is a long-acting analog of amylin and it has demonstrated significant weight loss in pre-clinical models of obesity.

More information: scientific publications

Next steps

The once-weekly amylin analog lead molecule for treatment of diabetes/obesity is anticipated to enter Phase 1 clinical testing in 2019.

The global prevalence of obesity has more than doubled since 1980. In 2014, more than 1.9 billion adults were classified as overweight and over 600 million of these were obese.*


Collaboration with Boehringer Ingelheim

Zealand has two collaborations with Boehringer Ingelheim, where they fund all research, development and commercialization activities. Zealand is eligible to receive royalties and milestone payments as follows:

Long-acting amylin analog

  • Initiation of Phase 1 trial triggered a milestone payment of EUR 4 million to Zealand

  • EUR 283 million outstanding in milestone payments

  • Mid single-digit to low double-digit percentage royalties on global sales