2005



2005

Petersen, J.S.:
ZP120 – Introduction of a new “First-in-Class” agent for the treatment of acute heart failure.
Presentation at the 60th Anniversary meeting of the Danish Society of Pharmacology and Toxicology, 7-8 December 2005

Haugan, K., Kjølbye, A.L., Hennan, J.K., and Petersen, J.S.:
Rotigaptide (ZP123) reverts established atrial conduction velocity slowing.
Cell Comm. Adhes. 2005, 12, 271–278

Editorial
Molecule of the month: Rotigaptide.
Drug News Perspect 18(9), November 2005

Hennan, J.K., Feldman, H.S., Swillo, R.E., Morgan, G.A., Keith Jr, J.C., Schaub, R.G., Smith, R.P., Haugan, K., Kantrowitz, J., Butera, J., and  Crandall, D.L.:
ZP123 Prevents Spontaneous Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs.
Poster at American Heart Association. Scientific Sessions 2005, November 13-16, 2005, Dallas, Texas, USA
Circulation, 2005, 112, No 17, II-16, Abstract No. 170

Axelsen, L.N., Mohammed, S., Kjølbye, A.L., Nielsen, M.S., Holstein-Rathlou, N.-H., Jensen, O.N., Andersen, S., Hennan, J.K., Stahlhut, M.:
Serine 297 and Serine 306: Two New Phosphorylation Sites Involved in the Regulation of Connexin43 during Ischemia.
Presentation at American Heart Association. Scientific Sessions 2005, November 13-16, 2005, Dallas, Texas, USA
Circulation, 2005, 112, No 17, II-114, Abstract No. 635

Dorian, P., Zhong, J., Hu, X., So, P.S.-S., Debicki, D., and Hennan, J.K.:
Increasing Gap Junction Conductance with ZP123 Improves Defibrillation Success in Experimental Cardiac Arrest.
Abstract submitted for American Heart Association. Scientific Sessions 2005, November 13-16, 2005, Dallas, Texas, USA
Circulation, 2005, 112, No 17, II-115, Abstract No. 637

Knudsen, C., Manniche, P., Jensen, T., Eeg, M., Moen, K., Thorkildsen, C., Petersen, J. and Ebbehøj, K.:
Dose-dependent pharmacokinetics of the novel peptide aquaretic ZP120 in both humans and rats.
The AAPS J, 2005, 7 (Issue 52, Supplement) Poster # T2311
Poster for AAPS Annual Meeting and Exposition, November 6-10, 2005 Nashville, TN, USA.

Haugan, K., Miyamoto, T., Takeishi, Y., Kubota, I., Nakayama, J., and Hirose, M.:
ZP123 improves atrial conduction slowing in chronic volume overload-induced dilated atria.
Abstract for European Society of Cardiology, Stockholm, Sept 2005
Eur Heart J, 2005, 26 (Suppl. 1), 511
Poster presentation

Jørgensen, N.R., Teilmann, S.C., Henriksen, Z, Meier, E., Hansen, S.S., Jensen, J.-E., Sørensen, O.H., and Petersen, J.S.:
The Antiarrhythmic Peptide Analog Rotigaptide (ZP123) Stimulates Gap Junction Intercellular Communication in Human Osteoblasts and Prevents Decrease in Femoral Trabecular Bone Strength in Ovariectomized Rats.
Endocrinology 2005, 146, 4745–4754

Stahlhut, M., Petersen, J.S., Hennan, J., and Ramirez, M.T.:
The anti-arrhythmic, gap junction modulator peptide ZP123 increases connexin 43 expression in neonatal rat cardiomyocytes by affecting protein turnover.
Poster 135 at The 2005 International Gap Junction Conference. August 13-18, Whistler, British Columbia, Canada. Abstract book p 223.
Poster Presentation

Martin, P.E.M., Clarke, T.C, Easton, J.A., Petersen, J.S., and Evans, W.H.:
The Antiarrhythmic Peptide ZP123 Increases Gap Junction Intercellular Communication in Cardiac Myocytes, Atrial HL-1 Cells, and Hela Cells Expressing Cx43.
Poster 93 at The 2005 International Gap Junction Conference. August 13-18, Whistler, British Columbia, Canada. Abstract book p 181.
Poster Presentation

Hennan, J.K., Swillo, R.E., Morgan, G.A., Haugan, and Crandall, D.L.:
ZP123 Prevents Spontaneous Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs.
Poster 52 at The 2005 International Gap Junction Conference. August 13-18, Whistler, British Columbia, Canada. Abstract book p 140.
Poster Presentation

Haugan, K., Olsen, K.B., Petersen, J.S., Holstein-Rathlou, N.-H., Hennan, J.K., and Nielsen, M.S.:
The Antiarrhythmic Peptide Analogue ZP123 Prevents and Reverts Atrial Conduction Slowing During Metabolic Stress.
Oral presentation at The 2005 International Gap Junction Conference. August 13-18, Whistler, British Columbia, Canada. Abstract book p 58.
Presentation

Axelsen, L.N., Mohammed, S., Kjølbye, A.L., Nielsen, M.S., Holstein-Rathlou, N.-H., Jensen, O.N., Andersen, S. Hennan, J.K., and Stahlhut, M.:
Characterization of connexin 43 phosphorylation during ischemia. Effect of the antiarrhythmic peptide analogue ZP123.
Oral presentation at The 2005 International Gap Junction Conference. August 13-18, Whistler, British Columbia, Canada. Abstract book p 31
Presentation

Knudsen,C.B., Thorkildsen, C., Petersen, J.S. and Ebbehøj, K.:
Dose-dependent pharmacokinetics of ZP120, a novel peptide aquaretic.
Poster PO-48 at Pharmaceutical Sciences Fair & Exhibition, June 12-17, 2005 Nice, France.
Drug metabolism reviews, 2005, 37 suppl. 1, A112.
Poster presentation

Axelsen, L.N., Mohammed, S., Kjølbye, A.L., Nielsen, M.S., Holstein-Rathlou, N.-H., Jensen, O.N., Andersen, S. Hennan, J.K., and Stahlhut, M.:
Characterization of connexin 43 phosphorylation during ischemia. Effect of the antiarrhythmic peptide analogue ZP123.
Presentation at DACRA´s 2005 Summer Meeting at The Sandbjerg Estate, 9-11 June 2005 ; abstract No. 2.

Hadrup, N., Petersen, J.S., Winfeldt, S., Risom, L., Christensen, S., and Janassen, T.E.N.:
Opioid receptor like-1 stimulation decreases the aquaporin-2 protein level and is a possible new treatment for hyponatremia.
Presentation at DACRA´s 2005 Summer Meeting at The Sandbjerg Estate, 9-11 June 2005 ; abstract No. 5.

Haugan, K., Olsen, K.B., Hartvig, L., Petersen, J.S., Holstein-Rathlou, N.-H., Hennan, J.K. and Nielsen, M.S.:
The Antiarrhythmic Peptide Analogue ZP123 Prevents and Reverts Atrial Conduction Slowing During Metabolic Stress.
Presentation at DACRA´s 2005 Summer Meeting at The Sandbjerg Estate, 9-11 June 2005 ; abstract No. 6.

Petersen, Y.M., Larsen, B.D., and Petersen, J.S.:
[Gly2]GLP-2 Administration Both Prior To And Concurrently With Chemotherapy Inhibits Small Intestinal Atrophy And Attenuates Body Weight Loss in Mice.
Poster at American Gastroenterological Association - Digestive Diseases Week. Chicago, Illinois, USA, May 12th-19th 2005.
Poster presentation

Kapusta, D.R., Thorkildsen, C., Kenigs, V.A., Meier, E., Vinge, M.M., Quist, C., and Petersen, J.S.:
Pharmacodynamic Characterization of ZP120 (Ac-RYYRWKKKKKKK-NH2), a Novel, Functionally Nociceptin/Orphanin FQ Peptide Receptor Partial Agonist with Sodium-Potassium-Sparing Aquaretic Activity.
J. Pharmacol. Exp. Ther. 2005, 314, 652-660

Guerra, J.M., Everett, T.H., Lee, K.W., Hennan, J., Wilson, E., and Olgin, J.E.:
Enhancement of cell coupling reduces AF vulnerability in a canine model of chronic mitral regulation.
Abstract from 26th Annual Scientific Sessions of Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana, USA.
Heart Rhythm, 2005, 2, No. 5, May Supplement, S96-S97

Haugan, K., Olsen, K.B., Hartvig, L., Petersen, J.S., Holstein-Rathlou, N.-H., Hennan, J.K. and Nielsen, M.S.:
The Antiarrhythmic Peptide Analogue ZP123 Prevents Atrial Conduction Slowing during Metabolic Stress.
J. Cardiovasc. Electrophysiol. 2005, 16, 537-545

Xing, D., Kjølbye, A.L., Petersen, J.S. and Martins, J.B.:
Pharmacological stimulation of cardiac gap junction coupling does not affect ischemia-induced focal ventricular tachycardia or triggered activity in dogs.
Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H511-H516

Haugan, K., Olsen, K.B., Hartvig, L., Petersen, J.S., Holstein-Rathlou, N.-H., Hennan, J.K. and Nielsen, M.S.:
The antiarrhythmic peptide analogue ZP123 prevents atrial conduction slowing during metabolic stress.
Poster B4 for Dansk Farmakologi 2005, 19 Januar, 2005, SDU, Odense, Denmark, Abstract
Poster presentation

Petersen, Y.M., Larsen, B.D. and Petersen, J.S.:
[Gly2]GLP-2 inhibits chemotherapy-induced small intestinal atrophy and body weight loss in mice.
Poster B6 for Dansk Farmakologi 2005, 19 Januar, 2005, SDU, Odense, Denmark, Abstract
Poster presentation

Hadrup, N., Petersen, J.S., Windfeld, S., Risom, L., Christensen, S. and Jonassen, T.E.N.:
Opioid receptor like 1 induced aquaresis is associated with a decreased protein level and decreased apical localization of aquaporin-2 in the rat kidney cortex.
Poster B8 for Dansk Farmakologi 2005, 19 Januar, 2005, SDU, Odense, Denmark 

 

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