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2008
27 November 2008: Announcement no. 3, 2008: Zealand Pharma and Helsinn Healthcare S...
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Product Pipeline
Zealand's Pipeline comprises 1 compound in phase III, 1 compound in phase II, 2 c...
2007
Sørensen, N.M., Hansen, L.E. and Knudsen, C.B.:
Validation of an anti-drug antibody ELISA for the detection of ZP120 antibodies in human serum
Poster for the American Association of Pharmaceutical Scientists Annual meeting, November 11-15, 2007, San Diego, CA, USA
AAPS Journal, 2007, vol. 9, No. S2, abstract W5007
Poster
Kjølbye, A.L.:
Rotigaptide: From Drug Discovery to Clinical Application
Presentation at The American Heart Association Meeting and Scientific Sessions 2007, Orlando, Florida, USA, Nov. 3-7, 2007.
Laurent, G., Leong-Poi,H., Moe, G., Hu, X., So, P.-S.S., Ramadeen, A., Doumanovskaia, L., and Konig, A.:
Effects of Oral Gap Junction Conduction-Enhancing Antiarrhythmic Peptide GAP-134 on Experimental Atrial Fibrillation in Dogs
Abstract from The American Heart Association Meeting and Scientific Sessions 2007, Orlando, Florida, USA, Nov. 3-7, 2007.
Rossman, E.I., Liu, K., Morgan, G.A., Swillo, R.E., Butera, J., Gruver, M., Kantrowitz, J., Haugan, K., Petersen, J.S. and Hennan, J.K.:
Effects of the Gap Junction Modifier, GAP-134, on Conduction and Atrial Fibrillation/Flutter Inducibility in Dogs
Abstract from The American Heart Association Meeting and Scientific Sessions 2007, Orlando, Florida, USA, Nov. 3-7, 2007.
Petersen, Y.M., Thorkildsen, C., Petersen, J.S. and Kjølbye, A.L:
ZP 1846, a Novel Potential Candidate for the Treatment of Chemotherapy-Induced Diarrhea
Abstract for Course: Gastrointestinal Response to Injury - Canada 2007.
3rd October – 6th October 2007, Montebello, Quebec, Canada
Larsen, B.D.:
Structure-inducing probes: Implications on synthesis, stability and pharmacological properties of peptides.
Presentation at Tides, Las Vegas, Nevada, USA, 21-23 Maj 2007.
Butera, J.A., Larsen, B.D., Kerns, K., Di, L., Hennan, J.K., Swillo, R., Morgan, G., Huselton, C., Unwalla, R. and Petersen, J.S.:
The Discovery of Potent Gap-junction Modifiers as Novel Antiarrhythmic Agents - From Stable Hexa-peptides to Orally Available Small Molecules.
Abstract for American Chemistry Society Fall Meeting 2007, August 19-23, 2007, Boston, MA, USA
Hennan, J.K., Liu, K., Morgan, G., Swillo, R., Butera, J., Kantrowitz, J., Haugan, K., Larsen, B.D., and Petersen, J.S.:
Pharmacological characterization of GAP-134, an orally bioavailable small molecule gap junction modifier, in mouse, rat and canine arrhythmia models
Abstract p 95, International Gap Junction Conference, Elsinore, Denmark, 4-7 August 2007
Larsen, B.D., Knudsen, C.B., Butera, J. and Petersen, J.S.:
Discovery of novel potent and selective antiarrhythmic peptides - from AAP10 to stable, orally available small molecules.
Abstract p 94, International Gap Junction Conference, Elsinore, Denmark, 4-7 August 2007
Martin, P., Petersen, J.S. and Easton, J.:
The Antiarrhythmic peptide AAP10 enhances Cx43 and Cx40 expression and functionality by a protein kinase C dependent mechanism
Abstract p 92, International Gap Junction Conference, Elsinore, Denmark, 4-7 August 2007
Kjølbye, A. L., Haugan, K., Hennan, J. K. and Petersen, J. S.:
Pharmacological Modulation of Gap Junction Function with the Novel Compound Rotigaptide: A Promising New Principle for Prevention of Arrhythmias
Basic & Clinical Pharmacology & Toxicology, 2007, 101, 215–230
Ellegaard, M., Stahlhut, M., Thorkildsen, C., Petersen, J.S., Pedersen, S., Jørgensen, N.R. and Schwarz, P.:
The effect of amylin(1-8) on bone in ovariectomized rats
Abstract for the 34th European Symposium on Calcified Tissue, Copenhagen, Denmark, 5-9 May 2007
Poster
Hadrup, N., Petersen, J.S., Windfeld, S., Risom, L., Andersen, C.B., Nielsen, S., Christensen, S. and Jonassen, T.E.N.:
Differential down-regulation of aquaporin-2 in rat kidney zones by peripheral nociceptin/orphanin FQ receptor agonism and vasopressin type-2 receptor antagonism
J Pharm Exp Ther, 2007, 323, 516-524
Petersen, Y.M., Thorkildsen, C., Petersen, J.S. and Kjølbye, A.L:
ZP 1846, a Novel Potential Candidate for the Treatment of Chemotherapy-Induced Diarrhea.
Poster: Multinational Association of Supportive Care in Cancer (MASCC) - 20th International Symposium «Supportive Care in Cancer». St.Gallen, Switzerland. 28 - 30 June 2007.
Support Care Cancer, 2007, 15, 772-773
Petersen, Y.M., Clausen, T.S., Kjølbye, A., Ørskov, A., Petersen, J.S. Larsen, B.D., Holst, J.J. and Poulsen, S.S.:
ZP1848, a new high efficacy glucagon-like peptide 2 mimetic, prevents indomethacin-induced inflammation in the small intestine in rats.
Annual meeting - Pharmacology of Membrane Proteins: from molecule to clinic. Joint meeting between The German Pharmacological Society and The Danish Society of Pharmacology and Toxicology, 21-22 June 2007, Copenhagen, Denmark
Poster Abstract No. 20, Meeting Programme p 41
Poster
Petersen, Y.M., Jepsen, T., Thorkildsen, C., Larsen, B.D., Petersen, J.S. and Kjølbye, A.:
ZP 1846, a novel stable, high efficacy glucagon-like peptide 2 mimetic, stimulates small intestinal growth and prevents 5-fluorouracil-induced small intestinal injury in c57bl mice.
Annual meeting - Pharmacology of Membrane Proteins: from molecule to clinic. Joint meeting between The German Pharmacological Society and The Danish Society of Pharmacology and Toxicology, 21-22 June 2007, Copenhagen, Denmark
Poster Abstract No. 19, Meeting Programme p 40
Poster
Axelsen, L.N., Haugan, K., Stahlhut, M., Kjølbye, A.-L., Hennan, J.K., Holstein-Rathlou, N.-H., Petersen, J.S., Nielsen, M.S.:
Increasing gap junctional coupling. A tool for dissecting the role of gap junctions.
J Membr Biol, 2007, 216, 23-35
Haugan, K. and Petersen, J.S.:
Gap junction modifying antiarrhythmic peptides: Therapeutic potential in atrial fibrillation.
Drugs of the Future, 2007, 32, 245-260
Shiroshita-Takeshita, A., Sakabe, M., Haugan, K., Hennan, J.K. and Nattel, S.:
Model-dependent effect of the Gap Junction conducting-enhancing antiarrhythmic peptide Rotigaptide (ZP123) on experimental atrial fibrillation in dogs.
Circulation 2007, 115, 310-318
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